HEF3/YNL014W Summary Help

Standard Name HEF3 1
Systematic Name YNL014W
Alias ZRG7 2
Feature Type ORF, Verified
Description Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Homolog of EF-3 1
Chromosomal Location
ChrXIV:606319 to 609453 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HEF3 GO evidence and references
  View Computational GO annotations for HEF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 11 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
38 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-purification: 1

Genetic Interactions
  • Negative Genetic: 2
  • Positive Genetic: 5
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,044
Molecular Weight (Da) 115,868
Isoelectric Point (pI) 6.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:606319 to 609453 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3135 606319..609453 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004959
References cited on this page View Complete Literature Guide for HEF3
1) Maurice TC, et al.  (1998) A highly conserved intraspecies homolog of the Saccharomyces cerevisiae elongation factor-3 encoded by the HEF3 gene. Yeast 14(12):1105-13
2) Yuan DS  (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
3) Sarthy AV, et al.  (1998) Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae. Yeast 14(3):239-53
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61