Standard Name	HDA3 (see Nomenclature conflict Note)
Systematic Name	YPR179C
Alias	PLO1
Feature Type	ORF, Verified
Description	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p (1, 2)
Name Description	Histone DeAcetylase 2

Chromosomal Location	ChrXVI:895764 to 893797 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for HDA3
Molecular Function
Manually curated	chromatin binding (IDA) DNA binding (IDA) contributes_to histone deacetylase activity (IDA)
Biological Process
Manually curated	chromosome segregation (IMP) gene silencing by RNA (IMP) gene silencing involved in chronological cell aging (IMP) histone deacetylation (IDA, IMP) negative regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	HDA1 complex (IDA, IPI)
High-throughput	nucleus (IDA)

Classical genetics
null	tellurium atom accumulation: increased Pot1-GFP accumulation: decreased histone H2B and H3 modification: increased silencing: increased
Large-scale survey
null	auxotrophy competitive fitness: decreased haploinsufficient metal resistance: increased mutation frequency: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to BPS: decreased resistance to amitrole: decreased resistance to arsenite(3-): decreased resistance to sodium arsenite: decreased resistance to cycloheximide: decreased stress resistance: decreased transposable element transposition: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	219 total interaction(s) for 160 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 87 Phenotypic Enhancement: 2 Positive Genetic: 10 Synthetic Growth Defect: 31 Synthetic Lethality: 25 Synthetic Rescue: 40
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:895764 to 893797 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1968 895764..893797 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006383