HDA1/YNL021W Summary 
HDA1 BASIC INFORMATION
| Standard Name | HDA1 |
|---|---|
| Systematic Name | YNL021W |
| Feature Type | ORF, Verified |
| Description | Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation (1, 2, 3, 4, 5, 6 and see Summary Paragraph) 
|
| Name Description | Histone DeAcetylase 1 |
| GO Annotations | All HDA1 GO evidence and references |
|---|---|
| View Computational GO annotations for HDA1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated |
|
| Cellular Component | |
| Manually curated |
|
| Mutant Phenotype | All HDA1 Phenotype details and references |
|---|---|
| Classical genetics | |
| null |
|
| Large-scale survey | |
| null |
| Interactions | HDA1 All interactions details and references |
|---|---|
| 211 total interaction(s) for 165 unique genes/features. | |
| Physical Interactions |
|
| Genetic Interactions |
|
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB |
|---|
| Primary SGDID | S000004966 |
|---|
HDA1 RESOURCES
| SGD ORF map | GBrowse |
|---|---|
|
Click on histogram for expression summary
Expression Summary
ADDITIONAL INFORMATION for HDA1
SUMMARY PARAGRAPH for HDA1
HDA1 encodes a histone deacetylase (1). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 7 and 8. Hda1p is part of a complex that also contains Hda3p (2). A second histone deactylase, Rpd3p, shows sequence similarity to Hda1p but is found in a complex distinct from the complex containing Hda1p (1); the two complexes affect transcription of distinct, partially overlapping sets of genes (1, 8). Deletion of HDA1 increases histone acetylation in vivo and increases telomeric repression of transcription (1). Three more histone deactylases, Hos1p, Hos2p, and Hos3p, have been identified in yeast; they share sequence similarity with Rpd3p and Hda1p but are less well characterized (1).
Last updated: 2000-01-10
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HDA1]
| 1) | Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 |
| 2) | Carmen AA, et al. (1996) HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. J Biol Chem 271(26):15837-44 |
| 3) | Bernstein BE, et al. (2000) Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A 97(25):13708-13 |
| 4) | Wu J, et al. (2001) TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast. Mol Cell 7(1):117-26 |
| 5) | Wu J, et al. (2001) HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc Natl Acad Sci U S A 98(8):4391-6 |
| 6) | Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 |
| 7) | Mizzen C, et al. (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81 |
| 8) | Suka N, et al. (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9 |
