HCA4/YJL033W Summary

HCA4 BASIC INFORMATION

Standard Name	HCA4
Systematic Name	YJL033W
Alias	DBP4 1 , ECM24
Feature Type	ORF, Verified
Description	Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis (1, 2)
Name Description	Helicase CA 2

GO Annotations	All HCA4 GO evidence and references
	View Computational GO annotations for HCA4
Molecular Function
Manually curated	ATP-dependent RNA helicase activity (IMP) RNA-dependent ATPase activity (IDA)
Biological Process
Manually curated	rRNA processing (IMP)
Cellular Component
Manually curated	nucleolus (IC)

Mutant Phenotype	All HCA4 Phenotype details and references
Large-scale survey
null	inviable
overexpression	filamentous growth: increased resistance to rapamycin: increased

Interactions	HCA4 All interactions details and references
	94 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 88 Biochemical Activity: 5
Genetic Interactions	Synthetic Growth Defect: 1

Sequence Information

ChrX:383831 to 386143 | |

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2313	383831..386143	2009-02-18	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003570

HCA4 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for HCA4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HCA4]

1)	Liang WQ, et al. (1997) The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein. Mol Cell Biol 17(7):4124-32
2)	Chang TH, et al. (1990) Identification of five putative yeast RNA helicase genes. Proc Natl Acad Sci U S A 87(4):1571-5

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