HCA4/YJL033W Summary Help

Standard Name HCA4 1
Systematic Name YJL033W
Alias DBP4 2 , ECM24
Feature Type ORF, Verified
Description DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis (2, 3, 4)
Name Description Helicase CA 3
Chromosomal Location
ChrX:383837 to 386149 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HCA4 GO evidence and references
  View Computational GO annotations for HCA4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
unspecified
Large-scale survey
null
overexpression
reduction of function
unspecified
Resources
110 total interaction(s) for 81 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 95
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 5
  • PCA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 1

Genetic Interactions
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 770
Molecular Weight (Da) 87,192
Isoelectric Point (pI) 7.44
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:383837 to 386149 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2313 383837..386149 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003570
References cited on this page View Complete Literature Guide for HCA4
1) Lussier M, et al.  (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147(2):435-50
2) Liang WQ, et al.  (1997) The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein. Mol Cell Biol 17(7):4124-32
3) Chang TH, et al.  (1990) Identification of five putative yeast RNA helicase genes. Proc Natl Acad Sci U S A 87(4):1571-5
4) Garcia I, et al.  (2012) Duplex destabilization by four ribosomal DEAD-box proteins. Biochemistry 51(50):10109-18