HAT1/YPL001W Summary Help

Standard Name HAT1 1
Systematic Name YPL001W
Feature Type ORF, Verified
Description Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair (1, 2, 3, 4, 5, 6)
Name Description Histone AcetylTransferase 1
Gene Product Alias KAT1 7
Chromosomal Location
ChrXVI:554605 to 555729 | ORF Map | GBrowse
Gene Ontology Annotations All HAT1 GO evidence and references
  View Computational GO annotations for HAT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
138 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 83
  • Affinity Capture-Western: 14
  • Co-fractionation: 1
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 3

Expression Summary
Length (a.a.) 374
Molecular Weight (Da) 43,872
Isoelectric Point (pI) 5.14
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:554605 to 555729 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1125 554605..555729 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005922
References cited on this page View Complete Literature Guide for HAT1
1) Kleff S, et al.  (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270(42):24674-7
2) Dutnall RN, et al.  (1998) Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell 94(4):427-38
3) Ruiz-Garcia AB, et al.  (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605
4) Parthun MR, et al.  (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94
5) Kelly TJ, et al.  (2000) Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 20(19):7051-8
6) Qin S and Parthun MR  (2002) Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair. Mol Cell Biol 22(23):8353-65
7) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6