HAT1/YPL001W Summary Help

Standard Name HAT1 1
Systematic Name YPL001W
Feature Type ORF, Verified
Description Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair (1, 2, 3, 4, 5, 6)
Name Description Histone AcetylTransferase 1
Gene Product Alias KAT1 7
Chromosomal Location
ChrXVI:554605 to 555729 | ORF Map | GBrowse
Gene Ontology Annotations All HAT1 GO evidence and references
  View Computational GO annotations for HAT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 53 genes
Regulators 108 genes
Classical genetics
Large-scale survey
138 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 83
  • Affinity Capture-Western: 14
  • Co-fractionation: 1
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 3

Expression Summary
Length (a.a.) 374
Molecular Weight (Da) 43,872
Isoelectric Point (pI) 5.14
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:554605 to 555729 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1125 554605..555729 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005922
References cited on this page View Complete Literature Guide for HAT1
1) Kleff S, et al.  (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270(42):24674-7
2) Dutnall RN, et al.  (1998) Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell 94(4):427-38
3) Ruiz-Garcia AB, et al.  (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605
4) Parthun MR, et al.  (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94
5) Kelly TJ, et al.  (2000) Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 20(19):7051-8
6) Qin S and Parthun MR  (2002) Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair. Mol Cell Biol 22(23):8353-65
7) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6