HAP5/YOR358W Summary Help

Standard Name HAP5 1
Systematic Name YOR358W
Feature Type ORF, Verified
Description Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex (1, 2)
Name Description Heme Activator Protein 1
Chromosomal Location
ChrXV:1010161 to 1010889 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HAP5 GO evidence and references
  View Computational GO annotations for HAP5
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 507 genes
Regulators 108 genes
Resources
Classical genetics
null
Large-scale survey
null
unspecified
Resources
223 total interaction(s) for 165 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • Reconstituted Complex: 8
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 164
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 19
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 242
Molecular Weight (Da) 27,675
Isoelectric Point (pI) 4.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:1010161 to 1010889 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..729 1010161..1010889 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005885
References cited on this page View Complete Literature Guide for HAP5
1) McNabb DS, et al.  (1995) Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. Genes Dev 9(1):47-58
2) McNabb DS, et al.  (1997) The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor. Mol Cell Biol 17(12):7008-18