HAP4/YKL109W Summary Help

Standard Name HAP4 1
Systematic Name YKL109W
Feature Type ORF, Verified
Description Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift (1, 2)
Name Description Heme Activator Protein 1
Chromosomal Location
ChrXI:232227 to 233891 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HAP4 GO evidence and references
  View Computational GO annotations for HAP4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 45 genes
Regulators 10 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
overexpression
Resources
129 total interaction(s) for 115 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Reconstituted Complex: 8
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 78
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 6
  • Positive Genetic: 11
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 554
Molecular Weight (Da) 62,411
Isoelectric Point (pI) 5.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:232227 to 233891 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1665 232227..233891 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001592
References cited on this page View Complete Literature Guide for HAP4
1) Forsburg SL and Guarente L  (1989) Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes Dev 3(8):1166-78
2) Zampar GG, et al.  (2013) Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast. Mol Syst Biol 9():651
3) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
4) Matys V, et al.  (2003) TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res 31(1):374-8