HAM1/YJR069C Summary

HAM1 BASIC INFORMATION

Standard Name	HAM1
Systematic Name	YJR069C
Feature Type	ORF, Verified
Description	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine (1, 2)
Name Description	6-n-HydroxylAMinopurine sensitive

GO Annotations	All HAM1 GO evidence and references
	View Computational GO annotations for HAM1
Molecular Function
Manually curated	nucleoside-triphosphate diphosphatase activity (IDA)
Biological Process
Manually curated	deoxyribonucleoside triphosphate catabolic process (IDA) response to DNA damage stimulus (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Mutant Phenotype	All HAM1 Phenotype details and references
Classical genetics
null	resistance to 5-bromodeoxyuridine: decreased resistance to 6-hydroxylaminopurine: decreased
overexpression	resistance to 5-bromodeoxyuridine: increased
Large-scale survey
null	viable

Interactions	HAM1 All interactions details and references
	3 total interaction(s) for 3 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Biochemical Activity: 1 Two-hybrid: 1

Sequence Information

ChrX:569391 to 568798 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2009-02-18 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..594	569391..568798	2009-02-18	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003830

HAM1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for HAM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HAM1]

1)	Noskov VN, et al. (1996) HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae. Yeast 12(1):17-29
2)	Burgis NE and Cunningham RP (2007) Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase. J Biol Chem 282(6):3531-8

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