GZF3/YJL110C Summary Help

Standard Name GZF3 1
Systematic Name YJL110C
Alias DEH1 2 , NIL2 3
Feature Type ORF, Verified
Description GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication (1, 2, 4, 5, 6, 7)
Name Description Gata Zinc Finger protein 1
Chromosomal Location
ChrX:211577 to 209922 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All GZF3 GO evidence and references
  View Computational GO annotations for GZF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 16 genes
Regulators 3 genes
Classical genetics
Large-scale survey
131 total interaction(s) for 125 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 6
  • PCA: 1
  • Two-hybrid: 70

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 36
  • Positive Genetic: 6
  • Synthetic Growth Defect: 1

Expression Summary
Length (a.a.) 551
Molecular Weight (Da) 60,519
Isoelectric Point (pI) 9.95
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:211577 to 209922 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1656 211577..209922 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003646
References cited on this page View Complete Literature Guide for GZF3
1) Soussi-Boudekou S, et al.  (1997) Gzf3p, a fourth GATA factor involved in nitrogen-regulated transcription in Saccharomyces cerevisiae. Mol Microbiol 23(6):1157-68
2) Coffman JA, et al.  (1997) Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. J Bacteriol 179(11):3416-29
3) Stanbrough M, et al.  (1995) Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc Natl Acad Sci U S A 92(21):9450-4
4) Rowen DW, et al.  (1997) Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces cerevisiae. J Bacteriol 179(11):3761-6
5) Bertram PG, et al.  (2000) Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. J Biol Chem 275(46):35727-33
6) Svetlov VV and Cooper TG  (1998) The Saccharomyces cerevisiae GATA factors Dal80p and Deh1p can form homo- and heterodimeric complexes. J Bacteriol 180(21):5682-8
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
9) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87