GYP1/YOR070C Summary Help

Standard Name GYP1
Systematic Name YOR070C
Alias YOR29-21
Feature Type ORF, Verified
Description Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion (1, 2, 3, 4, 5)
Name Description Gtpase-activating protein for YPt1p 1
Chromosomal Location
ChrXV:457820 to 455907 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GYP1 GO evidence and references
  View Computational GO annotations for GYP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All GYP1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All GYP1 Interaction evidence and references
584 total interaction(s) for 275 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 7
  • Reconstituted Complex: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Dosage Rescue: 1
  • Negative Genetic: 446
  • Phenotypic Suppression: 2
  • Positive Genetic: 39
  • Synthetic Growth Defect: 39
  • Synthetic Lethality: 39
  • Synthetic Rescue: 2
Resources
Expression Summary
histogram
Resources
Protein Information All GYP1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:457820 to 455907 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1914 457820..455907 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005596
References cited on this page View Complete Literature Guide for GYP1
1) Du LL, et al.  (1998) Identification of a Sec4p GTPase-activating protein (GAP) as a novel member of a Rab GAP family. J Biol Chem 273(6):3253-6
2) Albert S, et al.  (1999) Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases. EMBO J 18(19):5216-25
3) Jones S, et al.  (1998) Identification of regulators for Ypt1 GTPase nucleotide cycling. Mol Biol Cell 9(10):2819-37
4) Du LL and Novick P  (2001) Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p. Mol Biol Cell 12(5):1215-26
5) Wang L, et al.  (2003) Hierarchy of protein assembly at the vertex ring domain for yeast vacuole docking and fusion. J Cell Biol 160(3):365-74