GTS1/YGL181W Summary Help

GTS1 BASIC INFORMATION

Standard Name GTS1 1
Systematic Name YGL181W
Alias FHT1 2 , LSR1 3
Feature Type ORF, Verified
Description Arf3p GTPase Activating Protein (GAP) that localizes to endocytic patches; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms; localizes to nucleus and induces flocculation when overexpressed (1, 4, 5, 6, 7, 8, 9, 10, 11)
Name Description Glycine Threonine Serine repeat protein 1
GO Annotations All GTS1 GO evidence and references
    View Computational GO annotations for GTS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: stressResponse ( 607 )
Mutant Phenotype All GTS1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions GTS1 All interactions details and references
38 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 2
  • Protein-RNA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 21
Genetic Interactions
  • Dosage Rescue: 2
  • Synthetic Lethality: 4
  • Synthetic Rescue: 1
Sequence Information
ChrVII:157912 to 159102 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1191 157912..159102 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003149

GTS1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for GTS1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
LSR1Nomenclature conflictThe LSR1 name has been used both for the U2 snRNA encoded by LSR1/snR20 and for GTS1/YGL181W.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GTS1]

1) Mitsui K, et al.  (1994) The GTS1 gene, which contains a Gly-Thr repeat, affects the timing of budding and cell size of the yeast Saccharomyces cerevisiae. Mol Cell Biol 14(8):5569-78
2) Iha H, et al.  (2001) Functional correlation between the nuclear localization of Fht1p and its flocculation and heat tolerance activities in budding yeast Saccharomyces cerevisiae. J Biomed Sci 8(5):416-20
3) SGD  (2009) Gene name standardized from a GenBank/EMBL/DDBJ record
4) Yaguchi S, et al.  (1996) The pleiotropic effect of the GTS1 gene product on heat tolerance, sporulation and the life span of Saccharomyces cerevisiae. Biochem Biophys Res Commun 218(1):234-7
5) Bossier P, et al.  (1997) Constitutive flocculation in Saccharomyces cerevisiae through overexpression of the GTS1 gene, coding for a 'Glo'-type Zn-finger-containing protein. Yeast 13(8):717-25
6) Adams CA, et al.  (2003) The Gts1 protein stabilizes the autonomous oscillator in yeast. Yeast 20(6):463-70
7) Shen H, et al.  (2006) The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae. FEMS Yeast Res 6(6):914-23
8) Xu Z and Tsurugi K  (2007) Role of Gts1p in regulation of energy-metabolism oscillation in continuous cultures of the yeast Saccharomyces cerevisiae. Yeast 24(3):161-70
9) Yaguchi S, et al.  (2007) Localization of Gts1p in cortical actin patches of yeast and its possible role in endocytosis. Eur J Cell Biol 86(5):275-85
10) Smaczynska-de Rooij II, et al.  (2008) Yeast Arf3p Modulates Plasma Membrane PtdIns(4,5)P2 Levels to Facilitate Endocytosis. Traffic 9(4):559-73
11) Toret CP, et al.  (2008) Multiple pathways regulate endocytic coat disassembly in Saccharomyces cerevisiae for optimal downstream trafficking. Traffic 9(5):848-59