GTS1/YGL181W Summary Help

Standard Name GTS1 1
Systematic Name YGL181W
Alias FHT1 2 , LSR1 3
Feature Type ORF, Verified
Description Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations (1, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Name Description Glycine Threonine Serine repeat protein 1
Chromosomal Location
ChrVII:157906 to 159096 | ORF Map | GBrowse
Gene Ontology Annotations All GTS1 GO evidence and references
  View Computational GO annotations for GTS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 49 genes
Regulators 4 genes
Classical genetics
Large-scale survey
78 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 7
  • Biochemical Activity: 2
  • Protein-RNA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 29

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 4
  • Negative Genetic: 14
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 396
Molecular Weight (Da) 44,407
Isoelectric Point (pI) 7.46
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:157906 to 159096 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1191 157906..159096 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003149
References cited on this page View Complete Literature Guide for GTS1
1) Mitsui K, et al.  (1994) The GTS1 gene, which contains a Gly-Thr repeat, affects the timing of budding and cell size of the yeast Saccharomyces cerevisiae. Mol Cell Biol 14(8):5569-78
2) Iha H, et al.  (2001) Functional correlation between the nuclear localization of Fht1p and its flocculation and heat tolerance activities in budding yeast Saccharomyces cerevisiae. J Biomed Sci 8(5):416-20
3) SGD  (2009) Gene name standardized from a GenBank/EMBL/DDBJ record
4) Yaguchi S, et al.  (1996) The pleiotropic effect of the GTS1 gene product on heat tolerance, sporulation and the life span of Saccharomyces cerevisiae. Biochem Biophys Res Commun 218(1):234-7
5) Bossier P, et al.  (1997) Constitutive flocculation in Saccharomyces cerevisiae through overexpression of the GTS1 gene, coding for a 'Glo'-type Zn-finger-containing protein. Yeast 13(8):717-25
6) Tonozuka H, et al.  (2001) Analysis of the upstream regulatory region of the GTS1 gene required for its oscillatory expression. J Biochem 130(5):589-95
7) Saito T, et al.  (2002) Regulation of the Gts1p level by the ubiquitination system to maintain metabolic oscillations in the continuous culture of yeast. J Biol Chem 277(37):33624-31
8) Adams CA, et al.  (2003) The Gts1 protein stabilizes the autonomous oscillator in yeast. Yeast 20(6):463-70
9) Shen H, et al.  (2006) The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae. FEMS Yeast Res 6(6):914-23
10) Xu Z and Tsurugi K  (2007) Role of Gts1p in regulation of energy-metabolism oscillation in continuous cultures of the yeast Saccharomyces cerevisiae. Yeast 24(3):161-70
11) Yaguchi S, et al.  (2007) Localization of Gts1p in cortical actin patches of yeast and its possible role in endocytosis. Eur J Cell Biol 86(5):275-85
12) Smaczynska-de Rooij II, et al.  (2008) Yeast Arf3p Modulates Plasma Membrane PtdIns(4,5)P2 Levels to Facilitate Endocytosis. Traffic 9(4):559-73
13) Toret CP, et al.  (2008) Multiple pathways regulate endocytic coat disassembly in Saccharomyces cerevisiae for optimal downstream trafficking. Traffic 9(5):848-59