GTR2/YGR163W Summary Help

Standard Name GTR2
Systematic Name YGR163W
Feature Type ORF, Verified
Description Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD (1, 2, 3, 4, 5)
Name Description GTp binding protein Resemblance 1
Chromosomal Location
ChrVII:827552 to 828577 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GTR2 GO evidence and references
  View Computational GO annotations for GTR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant phenotypes All GTR2 Phenotype evidence and references
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
interactions All GTR2 Interaction evidence and references
59 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • PCA: 8
  • Reconstituted Complex: 9
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Growth Defect: 1
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 9
Resources
Expression Summary
histogram
Resources
Protein Information All GTR2 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:827552 to 828577 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1026 827552..828577 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003395
References cited on this page View Complete Literature Guide for GTR2
1) Nakashima N, et al.  (1999) Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152(3):853-67
2) Sekiguchi T, et al.  (2001) Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J Biol Chem 276(10):7246-57
3) Dubouloz F, et al.  (2005) The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol Cell 19(1):15-26
4) Gao M and Kaiser CA  (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8(7):657-67
5) Sekiguchi T, et al.  (2008) Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 368(3):748-54