GTR1/YML121W Summary Help

Standard Name GTR1 1
Systematic Name YML121W
Feature Type ORF, Verified
Description Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB (1, 2, 3, 4, 5, 6, 7)
Name Description GTp binding protein Resemblance 1
Chromosomal Location
ChrXIII:26930 to 27862 | ORF Map | GBrowse
Gbrowse
Genetic position: -99.6 cM
Gene Ontology Annotations All GTR1 GO evidence and references
  View Computational GO annotations for GTR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All GTR1 Phenotype evidence and references
Classical genetics
null
unspecified
Large-scale survey
null
unspecified
Resources
interactions All GTR1 Interaction evidence and references
265 total interaction(s) for 189 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 13
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-fractionation: 2
  • PCA: 11
  • Reconstituted Complex: 15
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 96
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 38
  • Positive Genetic: 28
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 3
  • Synthetic Rescue: 8
Resources
Expression Summary
histogram
Resources
Protein Information All GTR1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:26930 to 27862 | ORF Map | GBrowse
SGD ORF map
Genetic position: -99.6 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..933 26930..27862 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004590
References cited on this page View Complete Literature Guide for GTR1
1) Bun-Ya M, et al.  (1992) Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol Cell Biol 12(7):2958-66
2) Nakashima N, et al.  (1996) Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae. J Cell Sci 109 ( Pt 9):2311-8
3) Nakashima N, et al.  (1999) Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152(3):853-67
4) Hirose E, et al.  (1998) RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. J Cell Sci 111 ( Pt 1):11-21
5) Palecek SP, et al.  (2000) Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae. Genetics 156(3):1005-23
6) Gao M and Kaiser CA  (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8(7):657-67
7) Sekiguchi T, et al.  (2008) Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 368(3):748-54