GSP2/YOR185C Summary Help

Standard Name GSP2 1
Systematic Name YOR185C
Alias CNR2 2
Feature Type ORF, Verified
Description GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description Genetic Suppressor of Prp20-1 1
Chromosomal Location
ChrXV:682106 to 681444 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 98.6 cM
Gene Ontology Annotations All GSP2 GO evidence and references
  View Computational GO annotations for GSP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Large-scale survey
null
overexpression
Resources
48 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 4
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 6
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 220
Molecular Weight (Da) 24,990
Isoelectric Point (pI) 6.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:682106 to 681444 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 98.6 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..663 682106..681444 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005711
References cited on this page View Complete Literature Guide for GSP2
1) Belhumeur P, et al.  (1993) GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Mol Cell Biol 13(4):2152-61
2) Kadowaki T, et al.  (1993) Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J 12(7):2929-37
3) Lau D, et al.  (2000) Purification of protein A-tagged yeast ran reveals association with a novel karyopherin beta family member, Pdr6p. J Biol Chem 275(1):467-71
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76