GSP1/YLR293C Summary Help

GSP1 BASIC INFORMATION

Standard Name GSP1
Systematic Name YLR293C
Alias CNR1 1 , CST17 2
Feature Type ORF, Verified
Description Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog (1, 3, 4, 5, 6, 7, 8, 9)
Name Description Genetic Suppressor of Prp20-1 3
GO Annotations All GSP1 GO evidence and references
    View Computational GO annotations for GSP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All GSP1 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
overexpression
Interactions GSP1 All interactions details and references
172 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 31
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 39
  • Biochemical Activity: 6
  • Co-fractionation: 1
  • Co-purification: 2
  • Far Western: 1
  • Reconstituted Complex: 45
  • Two-hybrid: 29
Genetic Interactions
  • Dosage Rescue: 14
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1
Sequence Information
ChrXII:721432 to 720773 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..660 721432..720773 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004284

GSP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for GSP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GSP1]

1) Kadowaki T, et al.  (1993) Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. EMBO J 12(7):2929-37
2) Ouspenski II, et al.  (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem 270(5):1975-8
3) Belhumeur P, et al.  (1993) GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Mol Cell Biol 13(4):2152-61
4) Schlenstedt G, et al.  (1997) Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J 16(20):6237-49
5) Kunzler M and Hurt EC  (1998) Cse1p functions as the nuclear export receptor for importin alpha in yeast. FEBS Lett 433(3):185-90
6) Becker J, et al.  (1995) RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. J Biol Chem 270(20):11860-5
7) Lee A, et al.  (1994) Site-directed mutagenesis of the yeast PRP20/SRM1 gene reveals distinct activity domains in the protein product. Mol Gen Genet 245(1):32-44
8) Schlenstedt G, et al.  (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14(21):5367-78
9) Floer M and Blobel G  (1996) The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. J Biol Chem 271(10):5313-6