Standard Name	GSF2
Systematic Name	YML048W
Alias	ECM6
Feature Type	ORF, Verified
Description	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression (1, 2)
Name Description	Glucose Signaling Factor 2

Chromosomal Location	ChrXIII:178426 to 179637 | ORF Map | GBrowse

	View Computational GO annotations for GSF2
Molecular Function
Manually curated	unfolded protein binding (IMP)
Biological Process
Manually curated	protein folding (IMP) protein localization to cell surface (IGI, IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA)
High-throughput	cytoplasm (IDA) mitochondrial outer membrane (IDA)

Classical genetics
null	Hst3p-GFP accumulation: abnormal Hxt1p-GFP distribution: abnormal Gal2p-GFP distribution: abnormal utilization of carbon source: decreased
unspecified	resistance to hygromycin B: decreased
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to bleomycin: increased resistance to PM02734: increased resistance to dimethyl sulfoxide: increased resistance to fluconazole: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to sodium selenide: decreased resistance to L-canavanine: increased resistance to sorbate: decreased sporulation: decreased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: decreased
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	196 total interaction(s) for 151 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 2 Biochemical Activity: 4 PCA: 60 Protein-peptide: 3 Reconstituted Complex: 10
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 71 Positive Genetic: 26 Synthetic Growth Defect: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:178426 to 179637 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1212 178426..179637 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004511