GRX5/YPL059W Summary Help

Standard Name GRX5 1
Systematic Name YPL059W
Feature Type ORF, Verified
Description Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p (1, 2, 3, 4)
Name Description GlutaRedoXin 1
Chromosomal Location
ChrXVI:444579 to 445031 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GRX5 GO evidence and references
  View Computational GO annotations for GRX5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
Resources
31 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Co-localization: 1
  • PCA: 1
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 2
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 150
Molecular Weight (Da) 16,931
Isoelectric Point (pI) 4.66
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:444579 to 445031 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..453 444579..445031 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005980
References cited on this page View Complete Literature Guide for GRX5
1) Rodriguez-Manzaneque MT, et al.  (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol Cell Biol 19(12):8180-90
2) Grant CM, et al.  (2000) Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1490(1-2):33-42
3) Rodriguez-Manzaneque MT, et al.  (2002) Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes. Mol Biol Cell 13(4):1109-21
4) Belli G, et al.  (2002) Structure-function analysis of yeast Grx5 monothiol glutaredoxin defines essential amino acids for the function of the protein. J Biol Chem 277(40):37590-6