Standard Name	GRE3 1
Systematic Name	YHR104W
Feature Type	ORF, Verified
Description	Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Name Description	Genes de Respuesta a Estres (stress responsive genes) 1

Chromosomal Location	ChrVIII:323409 to 324392 | ORF Map | GBrowse

	View Computational GO annotations for GRE3
Molecular Function
Manually curated	alditol:NADP+ 1-oxidoreductase activity (IDA, ISS) D-xylose:NADP reductase activity (IDA, IMP) glucose 1-dehydrogenase (NADP+) activity (IDA) mRNA binding (IDA)
Biological Process
Manually curated	arabinose catabolic process (IDA, IMP) cellular response to oxidative stress (IGI) D-xylose catabolic process (IDA, IMP) galactose catabolic process (IGI) response to stress (IDA)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	xylose metabolism

Classical genetics
null	fermentative growth: decreased viable
overexpression	resistance to methylglyoxal: increased resistance to galactose and lithium chloride: increased
Large-scale survey
null	auxotrophy competitive fitness: decreased haploinsufficient resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	146 total interaction(s) for 130 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 5 Reconstituted Complex: 3
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 5 Negative Genetic: 84 Phenotypic Enhancement: 4 Positive Genetic: 26 Synthetic Growth Defect: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:323409 to 324392 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..984 323409..324392 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001146