GRE2/YOL151W Summary Help

Standard Name GRE2 1
Systematic Name YOL151W
Feature Type ORF, Verified
Description 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase (1, 2, 3, 4, 5, 6, 7)
Name Description Genes de Respuesta a Estres (stress responsive genes) 1
Chromosomal Location
ChrXV:43694 to 44722 | ORF Map | GBrowse
Gene Ontology Annotations All GRE2 GO evidence and references
  View Computational GO annotations for GRE2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 15 genes
Classical genetics
Large-scale survey
30 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Co-crystal Structure: 1
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 16
  • Positive Genetic: 3
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 342
Molecular Weight (Da) 38,169
Isoelectric Point (pI) 6.08
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:43694 to 44722 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1029 43694..44722 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005511
References cited on this page View Complete Literature Guide for GRE2
1) Garay-Arroyo A and Covarrubias AA  (1999) Three genes whose expression is induced by stress in Saccharomyces cerevisiae. Yeast 15(10A):879-92
2) Vido K, et al.  (2001) A proteome analysis of the cadmium response in Saccharomyces cerevisiae. J Biol Chem 276(11):8469-74
3) Rep M, et al.  (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40(5):1067-83
4) Chen CN, et al.  (2003) Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae. Yeast 20(6):545-54
5) Hauser M, et al.  (2007) A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. FEMS Yeast Res 7(1):84-92
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Jayakody LN, et al.  (2013) Engineering redox cofactor utilization for detoxification of glycolaldehyde, a key inhibitor of bioethanol production, in yeast Saccharomyces cerevisiae. Appl Microbiol Biotechnol 97(14):6589-600