GPX1/YKL026C Summary Help

Standard Name GPX1 1
Systematic Name YKL026C
Feature Type ORF, Verified
Description Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; GPX1 has a paralog, HYR1, that arose from the whole genome duplication (1, 2, 3)
Name Description Glutathione PeroXidase 1
Chromosomal Location
ChrXI:389883 to 389380 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GPX1 GO evidence and references
  View Computational GO annotations for GPX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
unspecified
Resources
17 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • PCA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 167
Molecular Weight (Da) 19,484
Isoelectric Point (pI) 8.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:389883 to 389380 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..504 389883..389380 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001509
References cited on this page View Complete Literature Guide for GPX1
1) Inoue Y, et al.  (1999) Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem 274(38):27002-9
2) Avery AM and Avery SV  (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276(36):33730-5
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61