GPI8/YDR331W Summary Help

Standard Name GPI8 1
Systematic Name YDR331W
Feature Type ORF, Verified
Description ER membrane glycoprotein subunit of the GPI transamidase complex; adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog (2, 3)
Name Description GlycosylPhosphatidylInositol anchor biosynthesis 1
Chromosomal Location
ChrIV:1129588 to 1130823 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GPI8 GO evidence and references
  View Computational GO annotations for GPI8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
repressible
Large-scale survey
null
overexpression
reduction of function
Resources
284 total interaction(s) for 225 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 1
  • PCA: 61

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Negative Genetic: 181
  • Phenotypic Enhancement: 2
  • Positive Genetic: 33

Resources
Expression Summary
histogram
Resources
Length (a.a.) 411
Molecular Weight (Da) 47,402
Isoelectric Point (pI) 4.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1129588 to 1130823 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1236 1129588..1130823 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002739
References cited on this page View Complete Literature Guide for GPI8
1) Benghezal M, et al.  (1995) Identification of six complementation classes involved in the biosynthesis of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae. J Cell Biol 130(6):1333-44
2) Benghezal M, et al.  (1996) Yeast Gpi8p is essential for GPI anchor attachment onto proteins. EMBO J 15(23):6575-83
3) Fraering P, et al.  (2001) The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p. Mol Biol Cell 12(10):3295-306