Standard Name	GPI18 1
Systematic Name	YBR004C
Feature Type	ORF, Verified
Description	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria (1, 2)
Name Description	GlycosylPhosphatidylInositol 1

Chromosomal Location	ChrII:245667 to 244366 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GPI18
Molecular Function
Manually curated	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity (IGI, IMP, ISA) mannosyltransferase activity (IGI, IMP, ISS)
Biological Process
Manually curated	GPI anchor biosynthetic process (IGI, IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA, ISS) integral to endoplasmic reticulum membrane (IDA) mannosyltransferase complex (IGI, IPI)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Retired Name	FMP44

Classical genetics
null	inviable
Large-scale survey
conditional	heat sensitivity: increased
null	heat sensitivity: increased inviable resistance to mefloquine: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	14 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 PCA: 2 Protein-RNA: 1
Genetic Interactions	Dosage Rescue: 2 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:245667 to 244366 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1302 245667..244366 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000208