Standard Name	GON7 1
Systematic Name	YJL184W
Alias	LDB6 1 , PCC2 2
Feature Type	ORF, Verified
Description	Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; implicated in osmotic stress response (1, 2, 3, 4, 5)

Chromosomal Location	ChrX:83448 to 83819 | ORF Map | GBrowse

	View Computational GO annotations for GON7
Molecular Function
Manually curated	chromatin DNA binding (IDA)
Biological Process
Manually curated	cell wall mannoprotein biosynthetic process (IMP) positive regulation of transcription from RNA polymerase II promoter (IPI) telomere maintenance (IMP)
Cellular Component
Manually curated	EKC/KEOPS complex (IDA) colocalizes_with nuclear chromatin (IDA)

Classical genetics
null	metal resistance: decreased
Large-scale survey
null	acid pH resistance: decreased bud morphology: abnormal competitive fitness: decreased inviable metal resistance: decreased oxidative stress resistance: decreased resistance to (S)-lactic acid: decreased resistance to acetic acid: decreased resistance to hydrogen chloride: decreased resistance to pentachlorophenol: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to boric acid: decreased resistance to glucose: decreased resistance to L-1,4-dithiothreitol: decreased resistance to doxorubicin: decreased resistance to glycolaldehyde: decreased resistance to sorbate: decreased resistance to sodium arsenite: increased resistance to oleate: decreased resistance to amiodarone: decreased resistance to oxalic acid: decreased respiratory growth: absent stress resistance: decreased transposable element transposition: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	40 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 4 Affinity Capture-Western: 1 Biochemical Activity: 1 Protein-peptide: 3 Two-hybrid: 11
Genetic Interactions	Negative Genetic: 2 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:83448 to 83819 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..372 83448..83819 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003720