Standard Name	GLR1
Systematic Name	YPL091W
Alias	LPG17
Feature Type	ORF, Verified
Description	Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)

Chromosomal Location	ChrXVI:375502 to 376953 | ORF Map | GBrowse

	View Computational GO annotations for GLR1
Molecular Function
Manually curated	glutathione-disulfide reductase activity (IDA)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) protein glutathionylation (IGI)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA)

Pathways	glutathione-glutaredoxin redox reactions glutathione-glutaredoxin system

Classical genetics
misexpression	oxidative stress resistance: decreased oxidative stress resistance: normal
null	budding index: decreased cell size: increased sulfide(2-) accumulation: decreased oxidative stress resistance: decreased resistance to DFD-VI-15: decreased resistance to diamide: decreased resistance to selenite(2-): decreased resistance to Dipyridyl disulfide: decreased resistance to selenium(2+): decreased
overexpression	metal resistance: increased
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased haploproficient hyperosmotic stress resistance: decreased oxidative stress resistance: decreased redox state: abnormal resistance to benzo[a]pyrene: decreased resistance to cadmium dichloride: decreased resistance to amitrole: decreased resistance to propan-1-ol: decreased resistance to sodium selenide: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	78 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 4 PCA: 2 Protein-peptide: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 43 Phenotypic Enhancement: 4 Phenotypic Suppression: 4 Positive Genetic: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 4 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:375502 to 376953 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1452 375502..376953 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006012