Standard Name	GIS2 1
Systematic Name	YNL255C
Feature Type	ORF, Verified
Description	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 (2, 3, 4, 5)
Name Description	GIg Suppressor 1

Chromosomal Location	ChrXIV:167790 to 167329 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GIS2
Molecular Function
Manually curated	mRNA binding (IDA) single-stranded DNA binding (IDA) translation regulator activity (IDA)
Biological Process
Manually curated	positive regulation of translation (IDA)
Cellular Component
Manually curated	cytoplasmic mRNA processing body (IDA) cytoplasmic stress granule (IDA) polysomal ribosome (IPI)
High-throughput	cytoplasm (IDA)

Classical genetics
null	resistance to fenpropimorph: decreased
Large-scale survey
null	bud morphology: abnormal cell size: increased competitive fitness: decreased resistance to caffeine: increased resistance to fluconazole: increased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: increased resistance to benzo[a]pyrene: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	1356 total interaction(s) for 1216 unique genes/features.
Physical Interactions	Affinity Capture-MS: 361 Affinity Capture-RNA: 937 Affinity Capture-Western: 5 PCA: 15 Protein-RNA: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 6 Negative Genetic: 22 Phenotypic Enhancement: 1 Positive Genetic: 4 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:167790 to 167329 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..462 167790..167329 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005199