GIS1/YDR096W Summary Help

GIS1 BASIC INFORMATION

Standard Name GIS1
Systematic Name YDR096W
Feature Type ORF, Verified
Description JmjC domain-containing histone demethylase; transcription factor involved in expression of genes during nutrient limitation and in negative regulation of DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis (1, 2, 3, 4, 5, 6)
Name Description GIg1-2 Suppressor 3
GO Annotations All GIS1 GO evidence and references
    View Computational GO annotations for GIS1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
High-throughput
Regulatory Role
Binding motifs
Mutant Phenotype All GIS1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions GIS1 All interactions details and references
  View additional details at BioGRID
61 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Two-hybrid: 19
Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 6
  • Negative Genetic: 13
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 7
  • Synthetic Growth Defect: 5
Sequence Information
ChrIV:637137 to 639821 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2685 637137..639821 2008-06-05 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002503

GIS1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for GIS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GIS1]

1) Jang YK, et al.  (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8
2) Pedruzzi I, et al.  (2000) Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J 19(11):2569-79
3) Balciunas D and Ronne H  (1999) Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Mol Gen Genet 262(4-5):589-99
4) Oshiro J, et al.  (2003) Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p. J Biol Chem 278(34):31495-503
5) Tu S, et al.  (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71
6) Zhang N and Oliver SG  (2010) The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis. J Biol Chem 285(9):6465-76
7) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87