GIR2/YDR152W Summary Help

Standard Name GIR2
Systematic Name YDR152W
Feature Type ORF, Verified
Description Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein (1, 2, 3, 4)
Name Description Genetically Interacts with Ribosomal genes 3
Chromosomal Location
ChrIV:765706 to 766503 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GIR2 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
overexpression
Large-scale survey
null
Resources
45 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 4
  • Co-fractionation: 1
  • PCA: 3
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 3
  • Positive Genetic: 12
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:765706 to 766503 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..798 765706..766503 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002559
References cited on this page View Complete Literature Guide for GIR2
1) Alves VS, et al.  (2004) Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior. Biochem Biophys Res Commun 314(1):229-34
2) Alves VS and Castilho BA  (2005) Gir2 is an intrinsically unstructured protein that is present in Saccharomyces cerevisiae as a group of heterogeneously electrophoretic migrating forms. Biochem Biophys Res Commun 332(2):450-5
3) Wout PK, et al.  (2009) Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1. Eukaryot Cell 8(7):1061-71
4) Daugeron MC, et al.  (2011) The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1. Nucleic Acids Res 39(6):2221-33