Standard Name	GIM5
Systematic Name	YML094W
Alias	PFD5
Feature Type	ORF, Verified
Description	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it (1, 2, 3)
Name Description	Gene Involved in Microtubule biogenesis 1

Chromosomal Location	ChrXIII:82275 to 82849 | ORF Map | GBrowse

	View Computational GO annotations for GIM5
Molecular Function
Manually curated	tubulin binding (IDA)
Biological Process
Manually curated	tubulin complex assembly (IMP, ISS)
Cellular Component
Manually curated	cytoplasm (IDA) prefoldin complex (IPI, ISS)

Classical genetics
null	cell size: increased chromosome/plasmid maintenance: abnormal cold sensitivity: increased resistance to benomyl: decreased resistance to hygromycin: decreased resistance to cycloheximide: decreased vegetative growth: decreased rate viable
Large-scale survey
null	cell size: increased competitive fitness: decreased competitive fitness: increased endocytosis: decreased fermentative growth: decreased rate heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to hygromycin B: decreased resistance to benomyl: decreased resistance to propan-1-ol: decreased resistance to methanol: decreased resistance to ethanol: decreased resistance to fenpropimorph: increased resistance to sodium arsenite: decreased resistance to pentachlorophenol: decreased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to mycophenolic acid: decreased resistance to cycloheximide: decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to doxorubicin: decreased resistance to sorbate: decreased respiratory growth: absent sporulation: decreased starvation resistance: decreased utilization of phosphorus source: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	995 total interaction(s) for 530 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 2 Affinity Capture-Western: 5 PCA: 2 Two-hybrid: 5
Genetic Interactions	Negative Genetic: 449 Phenotypic Enhancement: 10 Phenotypic Suppression: 4 Positive Genetic: 254 Synthetic Growth Defect: 166 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 77
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:82275 to 82849 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..16 82275..82290 1996-07-31 1996-07-31 Intron 17..99 82291..82373 1996-07-31 1996-07-31 CDS 100..575 82374..82849 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (17 - 99)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004559