GIM5/YML094W Summary Help

Standard Name GIM5 1
Systematic Name YML094W
Alias PFD5
Feature Type ORF, Verified
Description Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation (1, 2, 3, 4)
Name Description Gene Involved in Microtubule biogenesis 1
Chromosomal Location
ChrXIII:82275 to 82849 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GIM5 GO evidence and references
  View Computational GO annotations for GIM5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
997 total interaction(s) for 530 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • PCA: 2
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 451
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 4
  • Positive Genetic: 254
  • Synthetic Growth Defect: 166
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 77

Resources
Expression Summary
histogram
Resources
Length (a.a.) 163
Molecular Weight (Da) 18,356
Isoelectric Point (pI) 9.51
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:82275 to 82849 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..16 82275..82290 1996-07-31 1996-07-31
Intron 17..99 82291..82373 1996-07-31 1996-07-31
CDS 100..575 82374..82849 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004559
References cited on this page View Complete Literature Guide for GIM5
1) Geissler S, et al.  (1998) A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J 17(4):952-66
2) Vainberg IE, et al.  (1998) Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 93(5):863-73
3) Brew CT and Huffaker TC  (2002) The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics 162(3):1079-89
4) Millan-Zambrano G, et al.  (2013) The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation. PLoS Genet 9(9):e1003776