GIM4/YEL003W Summary Help

Standard Name GIM4 1
Systematic Name YEL003W
Alias PFD2
Feature Type ORF, Verified
Description Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it (1, 2, 3)
Name Description Gene Involved in Microtubule biogenesis 1
Chromosomal Location
ChrV:148176 to 148599 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GIM4 GO evidence and references
  View Computational GO annotations for GIM4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 62 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
922 total interaction(s) for 481 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Two-hybrid: 22

Genetic Interactions
  • Negative Genetic: 408
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 10
  • Positive Genetic: 219
  • Synthetic Growth Defect: 147
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 87

Resources
Expression Summary
histogram
Resources
Length (a.a.) 111
Molecular Weight (Da) 12,994
Isoelectric Point (pI) 8.39
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:148176 to 148599 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2007-07-09
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..19 148176..148194 2011-02-03 2007-07-09
Intron 20..107 148195..148282 2011-02-03 2007-07-09
CDS 108..424 148283..148599 2011-02-03 2007-07-09
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000729
References cited on this page View Complete Literature Guide for GIM4
1) Geissler S, et al.  (1998) A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J 17(4):952-66
2) Vainberg IE, et al.  (1998) Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell 93(5):863-73
3) Brew CT and Huffaker TC  (2002) The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics 162(3):1079-89