Standard Name	GIM4
Systematic Name	YEL003W
Alias	PFD2
Feature Type	ORF, Verified
Description	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it (1, 2, 3)
Name Description	Gene Involved in Microtubule biogenesis 1

Chromosomal Location	ChrV:148176 to 148599 | ORF Map | GBrowse

	View Computational GO annotations for GIM4
Molecular Function
Manually curated	tubulin binding (IDA)
Biological Process
Manually curated	tubulin complex assembly (IMP, ISS)
Cellular Component
Manually curated	cytoplasm (IDA) prefoldin complex (IPI, ISS)

Classical genetics
null	cell size: increased chromosome/plasmid maintenance: abnormal metal resistance: decreased resistance to benomyl: decreased viable
Large-scale survey
null	competitive fitness: decreased heat sensitivity: increased resistance to benomyl: decreased resistance to arsenite(3-): decreased resistance to ethanol: decreased resistance to oleate: decreased resistance to tunicamycin: increased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to camptothecin: increased resistance to bleomycin: increased resistance to cycloheximide: decreased resistance to wortmannin: decreased resistance to sodium arsenite: decreased resistance to caffeine: decreased resistance to benzo[a]pyrene: decreased toxin resistance: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	893 total interaction(s) for 472 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 2 Affinity Capture-Western: 3 Two-hybrid: 22
Genetic Interactions	Negative Genetic: 385 Phenotypic Enhancement: 4 Phenotypic Suppression: 10 Positive Genetic: 215 Synthetic Growth Defect: 147 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 87
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:148176 to 148599 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2007-07-09
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..19 148176..148194 2011-02-03 2007-07-09 Intron 20..107 148195..148282 2011-02-03 2007-07-09 CDS 108..424 148283..148599 2011-02-03 2007-07-09
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (20 - 107)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000729