GIM3/YNL153C Summary Help

Standard Name GIM3 1
Systematic Name YNL153C
Alias PFD4
Feature Type ORF, Verified
Description Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation (2, 3, 4)
Name Description Gene Involved in Microtubule biogenesis 1
Chromosomal Location
ChrXIV:346058 to 345669 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GIM3 GO evidence and references
  View Computational GO annotations for GIM3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 89 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
906 total interaction(s) for 410 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • PCA: 3
  • Two-hybrid: 16

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 421
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 186
  • Synthetic Growth Defect: 109
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 129
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 129
Molecular Weight (Da) 15,180
Isoelectric Point (pI) 4.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:346058 to 345669 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..390 346058..345669 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005097
References cited on this page View Complete Literature Guide for GIM3
1) Geissler S, et al.  (1998) A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J 17(4):952-66
2) Siegers K, et al.  (1999) Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. EMBO J 18(1):75-84
3) Brew CT and Huffaker TC  (2002) The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics 162(3):1079-89
4) Millan-Zambrano G, et al.  (2013) The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation. PLoS Genet 9(9):e1003776