Standard Name	GIM3
Systematic Name	YNL153C
Alias	PFD4
Feature Type	ORF, Verified
Description	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it (1, 2)
Name Description	Gene Involved in Microtubule biogenesis 3

Chromosomal Location	ChrXIV:346058 to 345669 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GIM3
Molecular Function
Manually curated	tubulin binding (IDA)
Biological Process
Manually curated	tubulin complex assembly (IMP, ISS)
Cellular Component
Manually curated	cytoplasm (IDA) prefoldin complex (IPI, ISS)

Classical genetics
null	cell size: increased cold sensitivity: increased resistance to benomyl: decreased vegetative growth: decreased rate viable
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased filamentous growth: increased mitochondrial genome maintenance: abnormal Fus-Mid-GFP distribution: abnormal resistance to wortmannin: normal resistance to sirolimus: decreased resistance to benomyl: decreased resistance to sodium arsenite: decreased resistance to sodium selenide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	848 total interaction(s) for 380 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 2 Affinity Capture-Western: 3 PCA: 3 Two-hybrid: 16
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 380 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 170 Synthetic Growth Defect: 109 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 129 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:346058 to 345669 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..390 346058..345669 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005097