GIC2/YDR309C Summary Help

Standard Name GIC2 1
Systematic Name YDR309C
Feature Type ORF, Verified
Description Redundant rho-like GTPase Cdc42p effector; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; GIC2 has a paralog, GIC1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description GTPase Interactive Component 1
Chromosomal Location
ChrIV:1080199 to 1079048 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All GIC2 GO evidence and references
  View Computational GO annotations for GIC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 27 genes
Classical genetics
Large-scale survey
120 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 27

Genetic Interactions
  • Dosage Growth Defect: 5
  • Dosage Lethality: 4
  • Dosage Rescue: 21
  • Negative Genetic: 18
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 3
  • Positive Genetic: 4
  • Synthetic Growth Defect: 5
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 11
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 383
Molecular Weight (Da) 42,852
Isoelectric Point (pI) 10.28
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:1080199 to 1079048 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1152 1080199..1079048 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002717
References cited on this page View Complete Literature Guide for GIC2
1) Brown JL, et al.  (1997) Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev 11(22):2972-82
2) Chen GC, et al.  (1997) The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae. Genes Dev 11(22):2958-71
3) Kawasaki R, et al.  (2003) The upstream regulator, Rsr1p, and downstream effectors, Gic1p and Gic2p, of the Cdc42p small GTPase coordinately regulate initiation of budding in Saccharomyces cerevisiae. Genes Cells 8(3):235-50
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Orlando K, et al.  (2008) Regulation of Gic2 Localization and Function by Phosphatidylinositol 4,5-Bisphosphate during the Establishment of Cell Polarity in Budding Yeast. J Biol Chem 283(21):14205-12