Standard Name	GIC1 1
Systematic Name	YHR061C
Feature Type	ORF, Verified
Description	Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress; GIC1 has a paralog, GIC2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	GTPase Interactive Component 1

Chromosomal Location	ChrVIII:222478 to 221534 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GIC1
Molecular Function
Manually curated	Rho GTPase activator activity (IDA, IGI, IPI) Rho GTPase binding (IPI)
Biological Process
Manually curated	axial cellular bud site selection (TAS) establishment of cell polarity (IGI) regulation of exit from mitosis (IMP, IPI) Rho protein signal transduction (TAS)
Cellular Component
Manually curated	actin cap (TAS) cellular bud neck (IDA) cellular bud tip (IDA) incipient cellular bud site (IDA) mating projection tip (IDA)
High-throughput	cellular bud tip (IDA) cytoplasm (IDA) nucleus (IDA)

Classical genetics
overexpression	cell size: increased cellular morphology: abnormal
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to amitrole: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
overexpression	silencing: abnormal vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	102 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 2 Reconstituted Complex: 6 Two-hybrid: 28
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 4 Dosage Rescue: 26 Negative Genetic: 5 Phenotypic Enhancement: 7 Phenotypic Suppression: 3 Synthetic Growth Defect: 4 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 7 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:222478 to 221534 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..945 222478..221534 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001103