Standard Name	GGA2 1
Systematic Name	YHR108W
Feature Type	ORF, Verified
Description	Protein that regulates Arf1p and Arf2p to facilitate Golgi traffickingi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Golgi-localized, Gamma-adaptin ear homology, Arf-binding protein 1

Chromosomal Location	ChrVIII:328303 to 330060 | ORF Map | GBrowse

	View Computational GO annotations for GGA2
Molecular Function
Manually curated	phosphatidylinositol-4-phosphate binding (IDA, IMP) ubiquitin binding (IDA, IMP)
Biological Process
Manually curated	Golgi to endosome transport (IMP) Golgi to vacuole transport (IMP, IPI) protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IMP)
Cellular Component
Manually curated	trans-Golgi network (IDA)

Classical genetics
null	Arn1p-GFP distribution: abnormal
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased hyperosmotic stress resistance: decreased metal resistance: increased resistance to clioquinol: decreased resistance to hygromycin B: decreased resistance to mefloquine: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	153 total interaction(s) for 86 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 1 Affinity Capture-Western: 13 Co-purification: 2 PCA: 4 Reconstituted Complex: 9 Two-hybrid: 16
Genetic Interactions	Negative Genetic: 51 Phenotypic Enhancement: 7 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Growth Defect: 13 Synthetic Lethality: 6 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:328303 to 330060 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1758 328303..330060 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001150