GET4/YOR164C Summary Help

Standard Name GET4 1
Systematic Name YOR164C
Alias ENV8 2
Feature Type ORF, Verified
Description Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 (1, 3, 4, 5)
Name Description Guided Entry Tail-anchored proteins 1
Chromosomal Location
ChrXV:644332 to 643394 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GET4 GO evidence and references
  View Computational GO annotations for GET4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
160 total interaction(s) for 76 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 7
  • Co-crystal Structure: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 8

Genetic Interactions
  • Negative Genetic: 52
  • Phenotypic Enhancement: 40
  • Phenotypic Suppression: 14
  • Positive Genetic: 5
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 312
Molecular Weight (Da) 36,280
Isoelectric Point (pI) 4.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:644332 to 643394 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..939 644332..643394 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005690
References cited on this page View Complete Literature Guide for GET4
1) Jonikas MC, et al.  (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
2) Ricarte F, et al.  (2011) A Genome-Wide Immunodetection Screen in S. cerevisiae Uncovers Novel Genes Involved in Lysosomal Vacuole Function and Morphology. PLoS One 6(8):e23696
3) Fleischer TC, et al.  (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
4) Fernandes JM, et al.  (2008) Genomic, evolutionary, and expression analyses of cee, an ancient gene involved in normal growth and development. Genomics 91(4):315-25
5) Chang YW, et al.  (2010) Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1. J Biol Chem 285(13):9962-70