GEP5/YLR091W Summary Help

Standard Name GEP5 1
Systematic Name YLR091W
Alias RRG5 2
Feature Type ORF, Verified
Description Protein of unknown function; required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine (1, 2, 3, 4)
Name Description GEnetic interactors of Prohibitins 1
Chromosomal Location
ChrXII:322297 to 323178 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GEP5 GO evidence and references
  View Computational GO annotations for GEP5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
158 total interaction(s) for 138 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 96
  • Positive Genetic: 51
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 293
Molecular Weight (Da) 33,868
Isoelectric Point (pI) 10.3
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:322297 to 323178 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..882 322297..323178 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004081
References cited on this page View Complete Literature Guide for GEP5
1) Osman C, et al.  (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96
2) Merz S and Westermann B  (2009) Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 10(9):R95
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54