GEP3/YOR205C Summary Help

Standard Name GEP3 1
Systematic Name YOR205C
Alias FMP38 2 , AIM40 3 , MTG3 4
Feature Type ORF, Verified
Description Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p) (1, 3, 4)
Name Description GEnetic interactors of Prohibitins 1
Chromosomal Location
ChrXV:727234 to 725564 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GEP3 GO evidence and references
  View Computational GO annotations for GEP3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
330 total interaction(s) for 280 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 232
  • Positive Genetic: 85
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 556
Molecular Weight (Da) 63,853
Isoelectric Point (pI) 10.07
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:727234 to 725564 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1671 727234..725564 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameLRC5
Primary SGDIDS000005731
References cited on this page View Complete Literature Guide for GEP3
1) Osman C, et al.  (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96
2) Rehling, P., et al.  (2004) personal communication
3) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
4) Paul MF, et al.  (2012) The putative GTPase encoded by MTG3 functions in a novel pathway for regulating assembly of the small subunit of yeast mitochondrial ribosomes. J Biol Chem 287(29):24346-55