GCY1/YOR120W Summary Help

Standard Name GCY1 1
Systematic Name YOR120W
Feature Type ORF, Verified
Description Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Also known as: GCY
Name Description Galactose-inducible Crystallin-like Yeast protein 8
Chromosomal Location
ChrXV:551114 to 552052 | ORF Map | GBrowse
Gene Ontology Annotations All GCY1 GO evidence and references
  View Computational GO annotations for GCY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Regulators 155 genes
Classical genetics
Large-scale survey
33 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • PCA: 1
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 17
  • Phenotypic Enhancement: 1
  • Positive Genetic: 4
  • Synthetic Growth Defect: 5
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 312
Molecular Weight (Da) 35,079
Isoelectric Point (pI) 8.16
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXV:551114 to 552052 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..939 551114..552052 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005646
References cited on this page View Complete Literature Guide for GCY1
1) Norbeck J and Blomberg A  (1997) Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway. J Biol Chem 272(9):5544-54
2) Costenoble R, et al.  (2000) Microaerobic glycerol formation in Saccharomyces cerevisiae. Yeast 16(16):1483-95
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Chang Q, et al.  (2007) Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Biochim Biophys Acta 1773(3):321-9
5) Tsvetanova NG, et al.  (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9)
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Jung JY, et al.  (2012) Characterization of GCY1 in Saccharomyces cerevisiae by metabolic profiling. J Appl Microbiol 113(6):1468-78
8) Angermayr M and Bandlow W  (2003) Permanent nucleosome exclusion from the Gal4p-inducible yeast GCY1 promoter. J Biol Chem 278(13):11026-31