GCN1/YGL195W Summary

GCN1 BASIC INFORMATION

Standard Name	GCN1
Systematic Name	YGL195W
Feature Type	ORF, Verified
Description	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA (1, 2)
Name Description	General Control Nonderepressible 3

GO Annotations	All GCN1 GO evidence and references
	View Computational GO annotations for GCN1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	regulation of translational elongation (IMP, IPI)
Cellular Component
Manually curated	cytosol (IDA) cytosolic ribosome (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All GCN1 Phenotype details and references
Large-scale survey
null	acid pH resistance: decreased resistance to ethanol: decreased resistance to St. John's Wort extract: decreased viable

Interactions	GCN1 All interactions details and references
	262 total interaction(s) for 198 unique genes/features.
Physical Interactions	Affinity Capture-MS: 72 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 PCA: 5 Reconstituted Complex: 2 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 117 Phenotypic Suppression: 47 Synthetic Growth Defect: 2

Sequence Information

ChrVII:131531 to 139549 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..8019	131531..139549	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003163

GCN1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for GCN1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GCN1]

1)	Kubota H, et al. (2001) Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2. J Biol Chem 276(20):17591-6
2)	Garcia-Barrio M, et al. (2000) Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation. EMBO J 19(8):1887-99
3)	Lucchini G, et al. (1984) Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae. Mol Cell Biol 4(7):1326-33

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