GCD11/YER025W Summary Help

GCD11 BASIC INFORMATION

Standard Name GCD11 1
Systematic Name YER025W
Alias SUI4 2
Feature Type ORF, Verified
Description Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met (3)
Name Description General Control Derepressed 4
GO Annotations All GCD11 GO evidence and references
    View Computational GO annotations for GCD11
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All GCD11 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions GCD11 All interactions details and references
179 total interaction(s) for 109 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 88
  • Affinity Capture-Western: 8
  • Co-fractionation: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 55
  • Synthetic Growth Defect: 3
Sequence Information
ChrV:205250 to 206833 | ORF Map | GBrowse
Gbrowse
Genetic position: 14 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1584 205250..206833 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000827

GCD11 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for GCD11

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GCD11]

1) Harashima S and Hinnebusch AG  (1986) Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol Cell Biol 6(11):3990-8
2) Huang HK, et al.  (1997) GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae. Genes Dev 11(18):2396-413
3) Laurino JP, et al.  (1999) The beta subunit of eukaryotic translation initiation factor 2 binds mRNA through the lysine repeats and a region comprising the C2-C2 motif. Mol Cell Biol 19(1):173-81
4) Lucchini G, et al.  (1984) Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae. Mol Cell Biol 4(7):1326-33