Standard Name	GCD11 1
Systematic Name	YER025W
Alias	SUI4 2
Feature Type	ORF, Verified
Description	Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) (3, 4)
Name Description	General Control Derepressed 5

Chromosomal Location	ChrV:205251 to 206834 | ORF Map | GBrowse
	Genetic position: 14 cM

	View Computational GO annotations for GCD11
Molecular Function
Manually curated	contributes_to GTP binding (IMP) translation initiation factor activity (IMP) contributes_to tRNA binding (IMP)
Biological Process
Manually curated	positive regulation of translational fidelity (IMP) translational initiation (IMP)
Cellular Component
Manually curated	eukaryotic translation initiation factor 2 complex (IMP) multi-eIF complex (IDA)

Classical genetics
null	inviable vegetative growth: decreased rate
reduction of function	vegetative growth: decreased rate vegetative growth: decreased vegetative growth: absent
Large-scale survey
null	inviable starvation resistance: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	231 total interaction(s) for 140 unique genes/features.
Physical Interactions	Affinity Capture-MS: 110 Affinity Capture-RNA: 1 Affinity Capture-Western: 22 Co-fractionation: 2 PCA: 1 Reconstituted Complex: 12 Two-hybrid: 7
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 8 Phenotypic Suppression: 4 Positive Genetic: 52 Synthetic Growth Defect: 5 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:205251 to 206834 | ORF Map | GBrowse
	Genetic position: 14 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1584 205251..206834 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000827