Standard Name	GCD10 1
Systematic Name	YNL062C
Alias	TRM6 2
Feature Type	ORF, Verified
Description	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression (3, 4, 5)
Name Description	General Control Derepressed 6
Gene Product Alias	1-methyladenosine tRNA methyltransferase subunit 3

Chromosomal Location	ChrXIV:510212 to 508776 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for GCD10
Molecular Function
Manually curated	contributes_to tRNA (adenine-N1-)-methyltransferase activity (IDA)
Biological Process
Manually curated	tRNA methylation (IDA)
Cellular Component
Manually curated	nucleus (IDA) tRNA (m1A) methyltransferase complex (IDA, IPI)

Classical genetics
conditional	tRNAiMet accumulation: decreased heat sensitivity: increased resistance to 3-aminotriazole: increased
Large-scale survey
null	inviable toxin resistance: decreased
overexpression	filamentous growth: increased
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	29 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 10 Co-crystal Structure: 1 Co-fractionation: 1 Co-purification: 3 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:510212 to 508776 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1437 510212..508776 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005006