GAR1/YHR089C Summary

GAR1 BASIC INFORMATION

Standard Name	GAR1
Systematic Name	YHR089C
Feature Type	ORF, Verified
Description	Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA (1, 2)

GO Annotations	All GAR1 GO evidence and references
	View Computational GO annotations for GAR1
Molecular Function
Manually curated	box H/ACA snoRNA binding (IPI)
Biological Process
Manually curated	rRNA processing (TAS) snRNA pseudouridine synthesis (IDA)
Cellular Component
Manually curated	box H/ACA snoRNP complex (IPI) nucleolus (IDA) small nucleolar ribonucleoprotein complex (IPI)

Mutant Phenotype	All GAR1 Phenotype details and references
Classical genetics
overexpression	cell cycle progression in G1 phase: abnormal
Large-scale survey
overexpression	vegetative growth: decreased
repressible	cell cycle progression: abnormal

Interactions	GAR1 All interactions details and references
	90 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 45 Affinity Capture-Western: 10 Biochemical Activity: 1 PCA: 24 Reconstituted Complex: 4 Two-hybrid: 3
Genetic Interactions	Synthetic Lethality: 3

Sequence Information

ChrVIII:283300 to 282683 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..618	283300..282683	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001131

GAR1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for GAR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GAR1]

1)	Bousquet-Antonelli C, et al. (1997) A small nucleolar RNP protein is required for pseudouridylation of eukaryotic ribosomal RNAs. EMBO J 16(15):4770-6
2)	Tremblay A, et al. (2002) A physical interaction between Gar1p and Rnt1pi is required for the nuclear import of H/ACA small nucleolar RNA-associated proteins. Mol Cell Biol 22(13):4792-802

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