GAB1/YLR459W Summary Help

Standard Name GAB1 1
Systematic Name YLR459W
Alias CDC91 1 , 2
Feature Type ORF, Verified
Description GPI transamidase subunit; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI (2)
Name Description GPI and Actin Bar 1
Chromosomal Location
ChrXII:1057334 to 1058518 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GAB1 GO evidence and references
  View Computational GO annotations for GAB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
conditional
null
repressible
Large-scale survey
conditional
null
repressible
Resources
84 total interaction(s) for 79 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 67
  • Positive Genetic: 4
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 394
Molecular Weight (Da) 44,741
Isoelectric Point (pI) 9.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:1057334 to 1058518 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1185 1057334..1058518 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004451
References cited on this page View Complete Literature Guide for GAB1
1) Grimme SJ, et al.  (2004) Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation. Mol Biol Cell 15(6):2758-70
2) Hong Y, et al.  (2003) Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Mol Biol Cell 14(5):1780-9