FIS1/YIL065C Summary

FIS1 BASIC INFORMATION

Standard Name	FIS1
Systematic Name	YIL065C
Alias	MDV2
Feature Type	ORF, Verified
Description	Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation (1, 2, 3)
Name Description	mitochondrial FISsion

GO Annotations	All FIS1 GO evidence and references
	View Computational GO annotations for FIS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chronological cell aging (IMP) mitochondrial fission (IGI, IMP) peroxisome fission (IGI) peroxisome organization (IMP)
High-throughput	response to drug (IMP)
Cellular Component
Manually curated	mitochondrial outer membrane (IDA) peroxisome (IDA)
High-throughput	mitochondrial outer membrane (IDA) mitochondrion (IDA)

Mutant Phenotype	All FIS1 Phenotype details and references
Classical genetics
null	peroxisomal morphology: abnormal resistance to hydrogen peroxide: decreased survival rate in stationary phase: increased viability: decreased
overexpression	cell cycle progression in G1 phase: abnormal
reduction of function	mitochondrial morphology: abnormal
Large-scale survey
null	acid pH resistance: decreased glycogen accumulation: decreased filamentous growth: decreased hyperosmotic stress resistance: decreased invasive growth: absent mitochondrial morphology: abnormal resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased
overexpression	vegetative growth: decreased

Interactions	FIS1 All interactions details and references
	46 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 7 Co-crystal Structure: 2 Co-localization: 4 Reconstituted Complex: 3 Two-hybrid: 16
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 3

Sequence Information

ChrIX:241772 to 241305 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..468	241772..241305	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001327

FIS1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FIS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FIS1]

1)	Mozdy AD, et al. (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80
2)	Kuravi K, et al. (2006) Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci 119(Pt 19):3994-4001
3)	Kitagaki H, et al. (2007) Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway. FEBS Lett 581(16):2935-42

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