FUS2/YMR232W Summary Help

Standard Name FUS2 1, 2
Systematic Name YMR232W
Feature Type ORF, Verified
Description Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p (2, 3, 4)
Name Description cell FUSion 1
Chromosomal Location
ChrXIII:736926 to 738959 | ORF Map | GBrowse
Gbrowse
Genetic position: 160 cM
Gene Ontology Annotations All FUS2 GO evidence and references
  View Computational GO annotations for FUS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
unspecified
Resources
71 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 12
  • Negative Genetic: 39
  • Phenotypic Enhancement: 7
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 677
Molecular Weight (Da) 79,036
Isoelectric Point (pI) 9.51
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:736926 to 738959 | ORF Map | GBrowse
SGD ORF map
Genetic position: 160 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2034 736926..738959 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004845
References cited on this page View Complete Literature Guide for FUS2
1) Trueheart J, et al.  (1987) Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol Cell Biol 7(7):2316-28
2) Elion EA, et al.  (1995) Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation. J Cell Biol 130(6):1283-96
3) Bagnat M and Simons K  (2002) Cell surface polarization during yeast mating. Proc Natl Acad Sci U S A 99(22):14183-8
4) Ydenberg CA, et al.  (2012) Cdc42p and Fus2p act together late in yeast cell fusion. Mol Biol Cell 23(7):1208-18