FUN26/YAL022C Summary Help

Standard Name FUN26 1
Systematic Name YAL022C
Feature Type ORF, Verified
Description High affinity, broad selectivity, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside (NmR) levels between the cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; equilibrative nucleoside transporter (ENT) family member (2, 3, 4)
Name Description Function Unknown Now 5
Chromosomal Location
ChrI:110430 to 108877 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All FUN26 GO evidence and references
  View Computational GO annotations for FUN26
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
13 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • PCA: 5
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 517
Molecular Weight (Da) 58,317
Isoelectric Point (pI) 4.79
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:110430 to 108877 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1554 110430..108877 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000000020
References cited on this page View Complete Literature Guide for FUN26
1) Barton AB and Kaback DB  (1994) Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the genes in the FUN38-MAK16-SPO7 region. J Bacteriol 176(7):1872-80
2) Vickers MF, et al.  (2000) Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes. J Biol Chem 275(34):25931-8
3) Lu SP and Lin SJ  (2011) Phosphate-responsive Signaling Pathway Is a Novel Component of NAD+ Metabolism in Saccharomyces cerevisiae. J Biol Chem 286(16):14271-81
4) Boswell-Casteel RC, et al.  (2014) Function Unknown Now 26 (FUN26) Protein from Saccharomyces cerevisiae is a Broad Selectivity, High-Affinity, Nucleoside and Nucleobase Transporter. J Biol Chem ()
5) Coleman KG, et al.  (1986) Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and characterization of the CDC24 gene and adjacent regions of the chromosome. Mol Cell Biol 6(12):4516-25