FUM1/YPL262W Summary

FUM1 BASIC INFORMATION

Standard Name	FUM1
Systematic Name	YPL262W
Feature Type	ORF, Verified
Description	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria (1, 2, 3, 4)
Name Description	FUMarase

GO Annotations	All FUM1 GO evidence and references
	View Computational GO annotations for FUM1
Molecular Function
Manually curated	fumarate hydratase activity (TAS)
Biological Process
Manually curated	fumarate metabolic process (TAS) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	cytosol (IDA) mitochondrial matrix (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Mutant Phenotype	All FUM1 Phenotype details and references
Classical genetics
null	acetic acid excretion: increased
Large-scale survey
null	competitive fitness: decreased respiratory growth: decreased rate respiratory growth: absent viable

Interactions	FUM1 All interactions details and references
	19 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6
Genetic Interactions	Synthetic Lethality: 12 Synthetic Rescue: 1

Sequence Information

ChrXVI:47336 to 48802 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1467	47336..48802	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006183

FUM1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FUM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FUM1]

1)	Przybyla-Zawislak B, et al. (1999) Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics 152(1):153-66
2)	Sass E, et al. (2003) Folding of fumarase during mitochondrial import determines its dual targeting in yeast. J Biol Chem 278(46):45109-16
3)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
4)	Regev-Rudzki N, et al. (2009) Dual localization of fumarase is dependent on the integrity of the glyoxylate shunt. Mol Microbiol 72(2):297-306

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