Standard Name	FUM1
Systematic Name	YPL262W
Feature Type	ORF, Verified
Description	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria (1, 2, 3, 4)
Name Description	FUMarase

Chromosomal Location	ChrXVI:47336 to 48802 | ORF Map | GBrowse

	View Computational GO annotations for FUM1
Molecular Function
Manually curated	fumarate hydratase activity (IDA)
Biological Process
Manually curated	fumarate metabolic process (IMP) tricarboxylic acid cycle (IMP)
Cellular Component
Manually curated	cytosol (IDA) mitochondrial matrix (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	reactive oxygen species accumulation: decreased reactive oxygen species accumulation: increased acetic acid excretion: increased respiratory growth: absent survival rate in stationary phase: increased survival rate in stationary phase: decreased utilization of carbon source: absent
Large-scale survey
null	competitive fitness: decreased resistance to sirolimus: decreased resistance to arsenite(3-): decreased resistance to glycolaldehyde: decreased resistance to wortmannin: decreased resistance to acetic acid: decreased resistance to neothyonidioside: decreased respiratory growth: decreased rate respiratory growth: absent toxin resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	172 total interaction(s) for 152 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8
Genetic Interactions	Negative Genetic: 83 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 61 Synthetic Growth Defect: 4 Synthetic Lethality: 12 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:47336 to 48802 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1467 47336..48802 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006183