Standard Name	FPK1 1
Systematic Name	YNR047W
Feature Type	ORF, Verified
Description	Ser/Thr protein kinase; regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane; FPK1 has a paralog, KIN82, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	FliPase Kinase 1 1

Chromosomal Location	ChrXIV:708523 to 711204 | ORF Map | GBrowse

	View Computational GO annotations for FPK1
Molecular Function
Manually curated	protein kinase activity (IDA, IMP) protein serine/threonine kinase activity (IDA, IMP)
Biological Process
Manually curated	positive regulation of phospholipid translocation (IGI) protein autophosphorylation (IDA) protein phosphorylation (IMP) response to pheromone (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) plasma membrane (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	Ypk1p-Myc modification: decreased
reduction of function	resistance to duramycin: decreased
unspecified	resistance to myriocin: decreased
Large-scale survey
null	competitive fitness: increased haploproficient resistance to fenpropimorph: decreased resistance to cycloheximide: decreased resistance to hydroxyurea: increased resistance to caffeine: increased resistance to bleomycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to wortmannin: increased resistance to sirolimus: increased resistance to fluconazole: decreased resistance to methyl methanesulfonate: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	115 total interaction(s) for 109 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 15 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 3 Negative Genetic: 55 Positive Genetic: 23 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:708523 to 711204 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2682 708523..711204 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005330