FOL2/YGR267C Summary

FOL2 BASIC INFORMATION

Standard Name	FOL2 1, 2
Systematic Name	YGR267C
Feature Type	ORF, Verified
Description	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway (1)
Name Description	FOLic acid synthesis

GO Annotations	All FOL2 GO evidence and references
	View Computational GO annotations for FOL2
Molecular Function
Manually curated	GTP cyclohydrolase I activity (IMP)
Biological Process
Manually curated	folic acid and derivative biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	folate biosynthesis pathways of chorismate

Mutant Phenotype	All FOL2 Phenotype details and references
Classical genetics
null	auxotrophy inviable
Large-scale survey
null	inviable resistance to sulfanilamide: decreased
overexpression	filamentous growth: increased
repressible	cell cycle progression in S phase: abnormal

Interactions	FOL2 All interactions details and references
	25 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 1 Biochemical Activity: 4 Two-hybrid: 7
Genetic Interactions	Dosage Lethality: 1

Sequence Information

ChrVII:1025741 to 1025010 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 215 cM

Last Update

Coordinates: 2005-11-29 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..732	1025741..1025010	2005-11-29	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003499

FOL2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for FOL2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FOL2]

1)	Nardese V, et al. (1996) Disruption of the GTP-cyclohydrolase I gene in Saccharomyces cerevisiae. Biochem Biophys Res Commun 218(1):273-9
2)	Game, J., et al. (1985) ; Personal Communication, Mortimer Map Edition 9

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