FOL2/YGR267C Summary Help

Standard Name FOL2 1, 2
Systematic Name YGR267C
Feature Type ORF, Verified
Description GTP-cyclohydrolase I; catalyzes the first step in the folic acid biosynthetic pathway (1)
Name Description FOLic acid synthesis
Chromosomal Location
ChrVII:1025735 to 1025004 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 215 cM
Gene Ontology Annotations All FOL2 GO evidence and references
  View Computational GO annotations for FOL2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
reduction of function
repressible
Resources
43 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 4
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 10
  • Positive Genetic: 4
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 243
Molecular Weight (Da) 27,769
Isoelectric Point (pI) 7.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:1025735 to 1025004 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 215 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..732 1025735..1025004 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003499
References cited on this page View Complete Literature Guide for FOL2
1) Nardese V, et al.  (1996) Disruption of the GTP-cyclohydrolase I gene in Saccharomyces cerevisiae. Biochem Biophys Res Commun 218(1):273-9
2) Game, J., et al.  (1985) ; Personal Communication, Mortimer Map Edition 9