FMT1/YBL013W Summary 
| Standard Name | FMT1 1 |
|---|---|
| Systematic Name | YBL013W |
| Feature Type | ORF, Verified |
| Description | Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate (1, 2 and see Summary Paragraph) |
| Name Description | Formyl-Methionyl-tRNA Transformylase |
| Gene Product Alias | methionyl-tRNA transformylase 1 |
| Chromosomal Location | |
|---|---|
|
Gene Ontology Annotations All FMT1 GO evidence and references
| View Computational GO annotations for FMT1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All FMT1 Phenotype evidence and references
| Classical genetics | |
|---|---|
| null | |
| Large-scale survey | |
| null |
|
| Resources |
interactions All FMT1 Interaction evidence and references
| 58 total interaction(s) for 55 unique genes/features. | |
| Physical Interactions |
|
| Genetic Interactions |
|
| Resources |
|
Expression Summary
|
| |
| Resources |
Protein Information All FMT1 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
|
| |||||||||||||
| Last Update | Coordinates: 2011-02-03 | Sequence: 2004-01-29 | ||||||||||||
| Subfeature details |
| ||||||||||||
| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
|---|
| Primary SGDID | S000000109 |
|---|
SUMMARY PARAGRAPH for FMT1
FMT1 encodes methionyl-tRNA formyltransferase, which catalyzes the formylation of initiator Met-tRNA (1). In yeast mitochondria, as in eubacteria and mitochondria from other eukaryotes, protein synthesis initiates with formylmethionine; eukaryotic cytosolic protein synthesis initiates with methionine (3). Although there is no formylation of the initiator Met-tRNA in cells lacking FMT1, the cells are viable and show normal mitochondrial protein synthesis and function (1).
Methionyl-tRNA formyltransferases have been identified in many prokaryotes and eukaryotes (1, 4). The structure of the E. coli enzyme has been determined (5, 6); a gene encoding mitochondrial methionyl-tRNA formyltransferase has been cloned from bovine liver (7).
Last updated: 2000-05-24 
References cited on this page View Complete Literature Guide for FMT1
| 1) | Li Y, et al. (2000) Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA. J Bacteriol 182(10):2886-92 |
| 2) | Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 |
| 3) | Kozak M (1983) Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. Microbiol Rev 47(1):1-45 |
| 4) | Gite S, et al. (2000) Escherichia coli methionyl-tRNA formyltransferase: role of amino acids conserved in the linker region and in the C-terminal domain on the specific recognition of the initiator tRNA. Biochemistry 39(9):2218-26 |
| 5) | Schmitt E, et al. (1996) Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase. EMBO J 15(17):4749-58 |
| 6) | Schmitt E, et al. (1998) Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet. EMBO J 17(23):6819-26 |
| 7) | Takeuchi N, et al. (1998) Expression and characterization of bovine mitochondrial methionyl-tRNA transformylase. J Biochem 124(6):1069-71 |
