MPC3/YGR243W Summary Help

Standard Name MPC3 1, 2
Systematic Name YGR243W
Alias FMP43 3 , 4
Feature Type ORF, Verified
Description Highly conserved subunit of mitochondrial pyruvate carrier; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress; MPC3 has a paralog, MPC2, that arose from the whole genome duplication (1, 2, 4, 5, 6, 7, 8, 9)
Name Description Mitochondrial Pyruvate Carrier 1, 2
Chromosomal Location
ChrVII:977336 to 977776 | ORF Map | GBrowse
Gene Ontology Annotations All MPC3 GO evidence and references
  View Computational GO annotations for MPC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 11 genes
Large-scale survey
16 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 5
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2

Expression Summary
Length (a.a.) 146
Molecular Weight (Da) 16,230
Isoelectric Point (pI) 11.28
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:977336 to 977776 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..441 977336..977776 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003475
References cited on this page View Complete Literature Guide for MPC3
1) Bricker DK, et al.  (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337(6090):96-100
2) Herzig S, et al.  (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337(6090):93-6
3) Meisinger, C., et al.  (2004) personal communication
4) Proft M, et al.  (2005) Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae. Eukaryot Cell 4(8):1343-52
5) Viladevall L, et al.  (2004) Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae. J Biol Chem 279(42):43614-24
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
8) Liu X, et al.  (2007) Genetic and Comparative Transcriptome Analysis of Bromodomain Factor 1 in the Salt Stress Response of Saccharomyces cerevisiae. Curr Microbiol 54(4):325-30
9) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76